Abstract
Background: Telemedicine has gained relevance in healthcare, especially after the COVID-19 pandemic. This study assesses knowledge and attitudes towards telemedicine in the Paraguayan population in order to identify areas for improvement and promote its effective adoption in the health system. Objective: To determine the knowledge and attitudes of the population towards telemedicine. Methodology: An observational, descriptive, cross-sectional study was conducted in 119 participants selected by non-probabilistic convenience sampling. An online survey was used to assess knowledge and attitudes towards telemedicine, considering socio-demographic variables and scores on definitions and perceptions related to telemedicine. Results: Participants showed an average score of 6.54 on telemedicine knowledge and 38.61 on attitudes. Most recognised key concepts, although some, such as teleconsultation, had low rates of understanding. Attitudes were positive, highlighting benefits such as accessibility and cost savings, but also mistrust and limitations in care. Discussion: The findings suggest a growing acceptance of telemedicine in Paraguay, similar to other Latin American contexts. However, barriers such as mistrust and perceived limitations persist. It is essential to implement targeted educational strategies to improve knowledge and address concerns, thus facilitating the adoption of telemedicine.

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